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Smith, Phase II Metabolism, UNC Chapel Hill, 8/2012 Reversible metabolism via enterohepatic cycling Liu and Smith, Current Drug Metabolism, 2006 EHC is not irreversible elimination, thus it acts as a distribution compartment for some drugs

A therapeutically effective amount is an amount sufficient to decrease, prevent or ameliorate the symptoms associated with a medical condition

Contains reduced form of glutathione (GSH), a form that can readily neutralize free radicals by donating electrons

The hybrid inhibitor-31c is a hybrid inhibitor targeting hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PHD2) and HDAC1/2/6

Third, glutamate generated from glutaminolysis is a precursor of glutathione, involved in maintaining redox balance (85)

doi: 10.1055/s-0028-1088314 31