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Although paraquat may not be an efficient inhibitor of mitochondrial complex I, and so does not affect dopamine uptake [87,88], it does cause -synuclein aggregation in C57Bl/6 mice, and alters Parkin solubility, decreasing proteasome activity and causing cellular damage [87]

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Cell Death Differ 15:18571864 Nurdiani R, Vasiljevic T, Singh TK, Donkor ON, Prihanto AA, Kusuma TS (2022) Stability of an anticancer peptide isolated from Flathead by-products during in vitro gastrointestinal digestion

This region includes tumor suppressor genes, CDKN2A which encodes for CDK4 and CDK6 inhibitor p16 INK4A and ARF encoding p14 which is a stabilizer of p53

Gut microbiota, innate immune pathways, and inflammatory control mechanisms in patients with major depressive disorder