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[DOI] [PubMed] [Google Scholar] Badamchian M., et al

Finding ways to expedite the soft tissue healing process, reduce inflammation, and restore functionality is crucial for individuals affected by such injuries

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In summary, the available data about the effect of buffers on the sensation of pain suggest that, in some cases, it is a consequence of the particular drugbuffer combination, as occurs in the case of bicarbonate and local anesthetics in which the buffering capacity of bicarbonate at pH 7 increases the activity of the anesthetics, thus reducing pain associated with the SC injection [51]