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This suggests LL-37 acts as an alarm system, redirecting mast cells from allergic mode to infection-fighting mode when bacteria are present

PMID 26924590

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Forced overexpression of GPX2 in preclinical models of OCSCC reduced production of inflammatory mediators by tumor cells, generated an aggressive in vivo tumorigenic profile, reduced infiltration of effector immunocytes and reduced effectiveness of cytotoxic T-lymphocytes-associated protein 4 (CTLA-4) inhibition