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18th Annual Targeted Therapies of Lung Cancer Meeting

doi: 10.1016/j.biocel.2020.105876 164 MokEHKLeeTKW

Abstract Autistic individuals with disproportionate megalencephaly (ASD-DM), characterized by enlarged brains relative to body height, have higher rates of intellectual disability and face more severe cognitive challenges than autistic children with average brain sizes

33,34 JNK translocates to mitochondria, binds to SH3 homologyassociated Brutons tyrosine kinase (BTK) binding protein (Sab) on the mitochondrial membrane, and subsequently inactivates a proto-oncogene tyrosine-protein kinase (Src) in mitochondria, eventually leading to the dysfunction of the ETC and the increased release of reactive oxygen species (ROS)

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Overall, HFD-mediated lipid accumulation induces lipotoxic stress pathways, ER stress, mitochondrial injury, and apoptosis, impairing granulosa cell viability and oocyte competence