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Diabetic retinopathy Mechanism: Chronic hyperglycemia damages retinal vessels causing microaneurysms, hemorrhages, edema, and eventually neovascularization

In BV-2 microglia, berberine down-regulates lipopolysaccharide- or interferon--induced iNOS and cyclooxygenase-2 (COX-2) level, and inhibits inflammatory cytokines expression (for example IL-6, IL-1, TNF-) (Lu et al., 2010)

Adequate B12 levels promote sharper focus, steady energy, and stronger overall vitality

Comment: Some commenters had concerns with the measure specifications

Description Amount per serving: Serving size: 5 ml (1 tsp.) Servings per container: 20 Ingredients: Thiamin (Vitamin B1) as thiamin hydrochloride 12,5 mg Riboflavin (Vitamin B2) (as Riboflavin 5-Phosphate) 7,5 mg Niacin (Vitamin B3) (as Niacin, Niacinamide) 10 mg Vitamin B6 (as Pyridoxine hydrochloride) 7,5 mg Folate (as Calcium folinate) 500 g Vitamin B12 (as Methylcobalamin) 500 g Biotin 500 g Pantothenic acid (as d-Calcium pantothenate) 25 mg Sodium 20 mg Opitac Glutathione 325 mg Betain Anhydrous (Trimethylglycine) 25 mg Milk Thistle Extract 57,5 mg Phospholipids (from purified sunflower seed lecithin) 400 mg Other Ingredients: Water, Glycerin, Ethanol, Vitamin E (as Tocofersolan and Natural Mixed Tocopherols), EDTA (as preservative) Natural Plant Flavoring (no MSG), Natural Citrus and Mint Oils

ROS function in redox Signaling and oxidative stress