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4 Ferroptosis defense systems 4.1 SLC7A11-GSH-GPX4 axis The main barrier that inhibits the path of ferroptosis is the redox of the cell, which is that it can instantly remove membrane phospholipid peroxide

Conclusions and future perspective Despite a large part of literature exploring on the accumulation and the origin of ROS, current antioxidant-based therapies lack of specificity for dysfunctional tissues, cells, and organelles, and thus may not reach an effective concentration at the target site of pathologic oxidative stress

doi: 10.1016/j.anireprosci.2015.08.012 71

Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency

Winkelstein JA: Chronic granulomatous disease

Late-life depression and risk of vascular dementia and Alzheimers disease: systematic review and meta-analysis of community-based cohort studies