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Consistently, CYP2E1-induced oxidative stress is modulated by the CYP2E1 inhibitors such as diallyl sulphide (DAS) and phenethyl isothiocyanate (PIC) in both in vivo and in vitro conditions [80, 16]

These effects were induced by inhibiting Gata2 expression while enhancing PU.1 levels [47]

Rare cases of allergic contact dermatitis have been described with prolonged copper exposure, so persistent or worsening inflammation should prompt discontinuation and medical evaluation