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Key points The choice of preclinical models should align with the current steatotic liver disease definition: cardiometabolic risk factors must be appropriately recapitulated to place metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH)-related hepatocellular carcinoma (HCC) models in the right metabolic context

Sleep better: Make sure your sleep hygiene is in tip-top shape (make time to wind down and keep your bedroom cool, dark, quiet, and comfortable)

If there isnt enough cysteine, the body cant produce enough glutathione, even if there are plenty of other amino acids, like glutamate and glycine

Glutathione (GSH), an abundant antioxidant that maintains a correct redox balance in cells, is essential for the protection of tumor cells against oxidative stress, such as stress induced by reactive oxygen species (ROS) 19,20,21,22,23

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Metabolites with relatively high fold decreases included Penitrem D, Bacilysin, and Dictagymnin