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Research by Heffernan et al

The "neurotrophin hypothesis of depression" proposes that depression results, at least in part, from reduced BDNF signaling in the hippocampus and prefrontal cortex

doi: 10.1146/annurev.immunol.23.021704.115707 [DOI] [PubMed] [Google Scholar] 101

Locating the source of alcohol would be evolutionarily advantageous in leading the organism to an abundance of food high in sugar and carbohydrates (18)

Its not really the craziest idea that something indigestible like gum could get stuck inside us until you remember how many indigestible things we eat all the time