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Future directions should include systems biology approaches to map these networks and develop highly selective receptor modulators to dissect specific signaling effects on the TIME

Inflammation mediates oxidative stress by producing reactive nitrogen and oxygen species, which mediate renal injury via apoptosis, necrosis and fibrosis [9, 23]

In this study, GSH inhibited ferroptosis by activating the SLC7A11/GPX4 axis and reducing LPO levels to ultimately alleviate graft injury and promote survival

(PubMed) Pozuelo-Moyano B, Benito-Leon J, Mitchell AJ, Hernandez-Gallego J

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We believe that this is due to the combined effort of three separate components glycine, cysteine (from NAC) and glutathione, and not just due to glutathione itself