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Epigallocatechin gallate (EGCG), a primary antioxidant in green tea, was used to prepare a therapeutic nano-agent via a rapid process involving five amino acids: lysine, arginine, leucine, glycine, and glutamic acid

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doi: 10.1016/j.theriogenology.2016.08.009 323 TurnerM

In that study, diet-induced obese (DIO) mice achieved higher clinical scores for disease phenotypes and were found to have increased inflammatory gene activation in the lungs following challenge

Studies suggest that lactate promotes pulmonary fibrosis through the ERK/DRP1 signaling pathway, which enhances mitochondrial fission-derived reactive oxygen species (ROS) production [110]

The ARISE-HF Phase 3 trial also evaluated AT-001 in patients with DbCM, particularly at high risk of progression to HF [154]