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Alterations in gene expression profiles during prostate cancer progression: functional correlations to tumorigenicity and down-regulation of selenoprotein-P in mouse and human tumors

Skeleton analysis was performed as described 60

The networks are interconnected via the Kelch-like ECH associated protein 1 (KEAP1) (Figure 3A)

In addition, research has shown that ROS produced in the mitochondria during T-cell activation affects Ca 2+ homeostasis in a concentration-dependent manner, activating the TF NFAT (107, 131)