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Because a substantial portion of freshly generated ATP in glycolytic cells is partitioned to energetically costly processes like protein synthesis [71], glucose sensing and phosphorylation of GATOR2 by AMPK is likely coupled to blockade of the protein synthetic machinery even when amino acids are present

Res Microbiol

Peptide therapy is a promising option in areas such as anti-aging, sports medicine, and chronic disease management

RNF34 is a cold-regulated E3 ligase responsible for the ubiquitination of PGC-1, a master regulator of thermogenesis, and negatively controls brown fat cell metabolism (Wei et al