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However, intracellular GSH at high concentrations inactivates ROS and reduces efficacy

216 Carnosic acid enhances the sensitivity to cisplatin by decreasing cell viability and increasing ferroptosis, and this effect can be reversed by the ferroptosis inhibitor liproxstatin-1, suggesting that ferroptosis is involved in carnosic acid-mediated cisplatin resistance

This dynamic interplay must be taken into consideration when targeting invasion in GBM

Saltiel, A

Organelle-specific localization of glutathione in plants grown under different light intensities and spectra