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In addition to the water-insoluble gum base, chewing gum preparations regularly contain a water-soluble component which is formed, for example, by softeners, sweeteners, fillers, flavours, flavour enhancers, emulsifiers, dyes, acidifiers, antioxidants and the like, with the proviso that the constituents have at least adequate solubility in water

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Xiao M, Xiao ZJ, Yang B, Lan Z, Fang F

Investigating the NRAS 5 UTR as a target for small molecules

However, the "safety" of a supplement also depends on its purity and how well your body can actually use it

Incorporation of a 5' cap structure enables cap-dependent translation initiation in circRNA