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For temporal interpolation (i.e., missing years between reported years) we used a thin plate spline to provide a smooth trend over time

quantified 4,405 proteins in murine hepatic organoids and observed differentiation-dependent upregulation of CYP450 enzymes, hepatic transporters, and other metabolic proteins, which parallels our observations in human iHLOs 14

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For each guideline recommendation, a gap was identified in levels of knowledge and skills required

Some users actually report better muscle gains, possibly due to improved insulin sensitivity and nutrient partitioning