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The activation of mast cells caused the destruction of neighboring chondrocytes and the breakdown of cartilage.[ref] Related article: Osteoarthritis genes The figure below is from a study on mast cells in osteoarthritis (OA), showing both increased numbers of mast cells and an increase in tryptase

Pharmacogenomic testing is increasingly used to guide personalized dosing, particularly for agents like capecitabine, where variants in the DPYD gene significantly affect drug metabolism and toxicity risk