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Then, they induced ferroptosis in the senescent cells to find they were far more sensitive to the cell death pathway than young, healthy cells

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852A is also an imidazoquinoline TLR7/8 agonist, which has previously been tested in multiple tumors types (including renal cell carcinoma, melanoma, lung cancer, hematologic malignancies, breast cancer, ovarian cancer, and cervical cancer), showing acceptable tolerability, evident immune stimulation, and clinical benefit in some patients (288291)