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PMID: 41857421 Am J Pathol Hyperglycemia induces tear reduction and dry eye in diabetic mice through the norepinephrine-1AR -mitochondrial impairment axis of lacrimal gland

Storing at Room Temperature Reconstituted peptides degrade rapidly above refrigerator temperature

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Front Oncol (2018) 8:404

Advanced glycation end products induce skeletal muscle atrophy and insulin resistance via activating ROS-mediated ER stress PERK/FOXO1 signaling

The UPR ER contains three upstream stress sensors in the ER membrane, i.e., inositol-requiring enzyme-1, PKR-like ER kinase, and ATF6, which is activated by the presence of unfolded proteins within the ER, ensuring signal transduction to the well-known downstream effector molecules