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[DOI] [PMC free article] [PubMed] [Google Scholar] 293.Cohen, J

These include: Lifestyle interventions (dietary advice, physical activity programmes) Licensed pharmacotherapy such as orlistat, or GLP-1 receptor agonists including semaglutide 2.4 mg (Wegovy, NICE TA875) or tirzepatide (Zepbound) where clinically indicated and available Referral to tier 3 or tier 4 weight management services , including bariatric surgery assessment where appropriate Information on NHS weight management services and eligibility for licensed treatments is available via the NHS website and NICE guidance

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[PubMed abstract] Lachner C, Martin C, John D, Nekkalapu S, Sasan A, Steinle N, et al

Human clinical trials reported an average weight loss of 2.6 kg over 12 weeks versus 0.8 kg in placebo groups