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As expected, BAK1 strongly trans-phosphorylated BIK1-Km protein (Supplemental Figure 5)

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In multiple neurodegenerative disease models, lipid-based nanoparticles, polymeric systems, vesicular carriers, and dendritic platforms consistently enhance brain accumulation and neuroprotective efficacy when rationally designed

Cell Immunol (1994) 158:25364.10.1006/cimm.1994.1272 17 PoncetPArockMDavidB

For example, a compelling animal or in vitro model might demonstrate a pathologic process analogous to human disease when a vaccine antigen is administered under conditions similar to human use