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As a small-molecule inhibitor targeting specific enzymatic activity, it has gained significant attention for its potential influence on adipocyte function, metabolic efficiency, and body-composition dynamics

In accordance with this theory is the reported weight loss effect of PYY3-36 when injected in rodents in the fasting state or in the early dark cycle times when NPY is naturally induced (172)

Soni KG, Lehner R, Metalnikov P, O'Donnell P, Semache M, Gao W, Ashman K, Pshezhetsky AV, Mitchell GA: Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase

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