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2009;58 Suppl 1:S13-S17

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Namely, redox-active metals, like Fe 2+ , react with peroxides generating highly active hydroxyl radicals (R-HO ) that further propagate the peroxidation reaction ( Cysteine, Lipid Peroxides and Ferroptosis Glutathione-Dependent Ferroptosis Since characterization of ferroptosis in 2012, the cysteine-GSH-GPx4 axis is described as essential pathway for its regulation, and thus seen as potential therapeutic target

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[DOI] [PubMed] [Google Scholar] 66.Belosic Halle Z., Vlainic J., Drmic D., Strinic D., Luetic K., Sucic M., Medvidovic-Grubisic M., Pavelic Turudic T., Petrovic I., Seiwerth S., et al