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Both lipoic acid and dihydrolipoic acid can directly scavenge (neutralize) physiologically relevant ROS and RNS in the test tube (reviewed in 3)

The overall direction of these changes moves gene expression patterns from states associated with disease and aging toward healthier profiles

However, it's important to understand that this is primarily a surface phenomenon

The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells

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In addition, participants in the exercise group were found to have 21% lower odds of rapid eGFR decline (defined as a decline of 6.7% per year), suggesting this exercise program may help preserve kidney function