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Acknowledgments This work was supported by the Core Facility of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine

While topical applications of GHK-Cu in cosmetics may remain largely unaffected, the injectable and compounded forms will be subject to the new Category 2 restrictions

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The quality check and trimming of sequences were done as described earlier

You may represent glutathione as G-SH, and you may use any acidic or basic amino acid residues from the enzyme active site that you wish (use Enz: for a base and Enz-H for an acid)