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Dose and Testing Oral B12 supplements are available at very high doses (500 to 2000 mcg) because oral absorption is inefficient only a small percentage of high-dose oral B12 is absorbed through a passive mechanism that bypasses intrinsic factor

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This is a common, but plausible statement to explain low in vitro-activities or salt sensitivities, because most of the antimicrobial peptides are produced for acting in short time intervals and after release from storage granules the peptides can locally reach remarkable high amounts as known from defensins [116]