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Next, based on the 16S rRNA gene sequencing results, the metabolic function of the samples flora was predicted, the differential pathways were identified, and the species composition of specific pathways was obtained

Intermittent fasting on human health and disease

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Metabolomics-based research may further reveal valuable biomarkers for therapy monitoring, as the reprogramming of ammonium metabolism in prostate cancer generates a range of intermediate metabolites, such as polyamines, citrate, and various amino acids, as well as key metabolic enzymes, which hold promise as indicators of therapeutic response (284)

67, 68 Interestingly, MM-derived exosomes (containing TYRP2, VLA4, HSP70, MET, and Rab27a proteins) can have an impact on cells and organs both locally and at distant sites (lymph nodes, bone marrow), with a net effect of enhancing invasion and priming a metastatic niche