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acnes significantly reduced the abundance of beneficial bacteria in model group, including Bacillus , Bacteroides , and Bifidobacterium [50, 78,79,80], while simultaneously increasing the abundance of pathogenic bacteria such as Stenotrophomonas and Delftia [81,82,83]

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(2) 1843: Johann Scherer detected lactate in human blood during shock, initially fueling its reputation as a harmful byproduct of hypoxia

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Nat Med 22:771779 Elrod JW, Calvert JW, Morrison J, Doeller JE, Kraus DW, Tao L, Jiao X, Scalia R, Kiss L, Szabo C, Kimura H, Chow C-W, Lefer DJ (2007) Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function