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Zhu JH, De Mello RA, Yan QL, Wang JW, Chen Y, Ye QH, et al

Thus, Cys in proteins must display low pKa, to enhance the thiolate fraction, as a prerequisite for fast and efficient oxidation by peroxides, although its nucleophilicity (to attack the H 2 O 2 electrophile) and its capacity to stabilize both the transition state with the reactant, H 2 O 2 , and the leaving group (which occurs after the rupture of the peroxidic bond) also has to be preserved [2,3,4]

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The microtubule-associated protein 1A/1B-light chain 3 (LC3) is a soluble protein that is distributed ubiquitously in mammalian cells

10.1002/adhm.202100683 Summary Keywords system Xc -/GSH/GPX4 axis, ferroptosis, drug resistance, solid tumor, therapy Citation Li F-J, Long H-Z, Zhou Z-W, Luo H-Y, Xu S-G and Gao L-C (2022) System X c /GSH/GPX4 axis : An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy

PubMed Research indicates that retinoids including retinol remain the gold standard for topical anti-aging treatments, though their application is frequently limited by skin irritation and poor tolerability, particularly in sensitive or aged populations