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Acknowledgments We thank Haiyan Yu, Xiaomin Zhao and Yuyu Guo from Core Facilities for Life and Environmental Sciences of SKLMT (State Key Laboratory of Microbial Technology, Shandong University) for the assistance in LSM900 Super Resolution Laser Scanning Confocal Microscope analysis

"[These] outweigh the negative effects that become more common with bigger doses such as nausea, panic, paranoia, agitation and gurning

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The IRIS 203 trial showed that pioglitazone reduced the incidence of any stroke in nondiabetic patients with IR and stroke, suggesting that pioglitazone has glucose-independent cardiovascular benefits