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Elevated cortisol levels, in turn, exacerbate microglial activation and inflammatory signaling, establishing a self-perpetuating cycle of stress, immune activation, and neuronal dysfunction (32, 33)

6C and Supplementary Fig

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Inhalational anesthetics and opioids are known to increase the levels of immunosuppressive cytokines, such as IL-4, IL-10 and TGF-, generating a feedback loop that intensifies the expansion of MDSCs and impairs antitumor immunity [69]

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