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Leko MB, Gunjaa I, Plei N, Zemunik T

These effects lead to hippocampus-dependent cognitive loss, including difficulties with spatial learning and memory, as well as neurodegeneration, inflammation, and synaptic malfunction

BMJ 2003;327:55760

Species interaction at the cellular level, dispersion or intercellular lipids extraction, increased fluidity of stratum corneum lipid bilayers, higher drug thermodynamic activity, and greater SC hydration are all mechanisms that support drug administration using chemical enhancers [283]