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During fetal and early postnatal life, adequate maternal thyroid hormone supply is critical for neurogenesis, neuronal migration, synaptogenesis, and myelination ( The entry of thyroid hormones into the central nervous system depends on specialized transporters at the BBB ( Within the brain, deiodinase enzymes modulate local hormone availability ( At the cellular level, thyroid hormones act through nuclear receptors TR and TR to regulate transcription of genes involved in neuronal metabolism, mitochondrial biogenesis, and cytoskeletal organization ( 3.2 Hypothyroidism and central nervous system dysfunction Hypothyroidism affects the central nervous system in ways that extend beyond metabolic slowing

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2021 EULAR recommendations regarding lifestyle behaviours and work participation to prevent progression of rheumatic and musculoskeletal diseases

Resveratrol, found in grapes and berries, offers anti-inflammatory and antioxidative properties, potentially curbing neurodegenerative processes initiated by concussions

Yu et al., 2004), as well as decrease heart rate (Wong et al., 2000) and inhibit hypertrophy (Yu et al., 2004)