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Beyond GSH metabolism, Nrf2 also promotes intracellular NADPH generation by upregulating the expression of genes related to the pentose phosphate pathway, which contains the key enzyme G6PD, as well as genes involved in pyruvate cycling and folate metabolism (166)

Cervical Injury

Introduction Cataracts Cataracts, characterized by progressive opacification of the ocular lens, are the leading cause of visual impairment and blindness worldwide (1)

The compound progressed through Phase 2 trials under ConjuChem in the mid-2000s for indications including HIV-associated lipodystrophy, but did not advance to a marketed therapeutic in any major jurisdiction

Antimicrobial Phototoxicity Borrelia and co-infections possess endogenous porphyrins

However, acquired resistancenow a major clinical limitationhas been linked to DPP9 overexpression (255)