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2018;16: e2006203

10.1002/ptr.7136

Inflammation leads to the overproduction of NADPH oxidases subunits, impaired antioxidant defense systems

The use of medicinal cannabis may be associated with a reduction in depressive symptoms, although the effects vary according to the cannabinoid profile and duration of use

Critically, glutamine/glutamate can provide additional energy to the TCA cycle by providing extra alpha-ketoglutarate (-KG) and succinate as shown in Fig