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Parker A, Fonseca S, Carding SR

Normally, Tyr-274 of this enzyme links to a specific phosphate in the DNA via a 3 1 - phosphodiester bond W topoisomerase forms a covalent protein-DNA intermediate at recognition sites in duplex DNA

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However, R min and R max are not measurable parameters on FACS because we cannot manipulate the intracellular GSH level to zero or saturating conditions