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The CON-39 C HS group, 39 C HS -39 C DF group, and 39 C HS -39 C HX group were screened for 129 (mainly nucleosides, nucleotides and analogs, lipid and lipid-like molecules, organic acids and their derivatives, and organic heterocyclic compounds), 121 (mainly nucleosides, nucleotides and analogs, organic acids and their derivatives, organic heterocyclic compounds, lipid and lipid-like molecules), 83 (mainly lipid and lipid-like molecules, benzene ring-type compounds, organic acids, and their derivatives) differential metabolites, respectively

You shouldn't have these injections if you have heart problems, severe anxiety, or other chronic medical issues

Studies have demonstrated that celastrol inhibits the PI3K/AKT/mTOR signaling pathway, increases the autophagosome level of FLS, decreases the phosphorylation of mTOR and AKT, and induces autophagy, thus ameliorating RA (234)

Storage Solvent & Solubility In Vitro : DMSO : 250 mg/mL ( 1495.57 mM

Acknowledgements This study was supported by the research fund of Dankook University in 2025

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