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Collectively, these studies support the contention that optimally functioning antioxidant selenoproteins may be crucial for reducing excess free radical accumulation and preventing oxidative tissue damage during acute or chronic inflammation

Free Radic Biol Med 34:103110 Sato H, Tamba M, Kuriyama-Matsumura K, Okuno S, Bannai S (2000) Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc

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tretinoin accelerates the shedding of pigmented cells and disperses melanin granules, together addressing dyspigmentation through two independent and complementary pathways

Fenton TR, Kim JH