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F-AFE inhibited Lyn, Fyn, Syk phosphorylation, involved in FcR1 signaling, and phosphoinositide phospholipase C (PLC) 1/2 and protein kinase C (PKC) phosphorylation, associated with degranulation processes, as well as Extracellular Signal-Related Kinases (ERK) 1/2, JNK, p38, and Akt phosphorylation, associated with cytokine expression [83]

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Third, water-soluble hydropersulfides may directly reduce chain-propagating lipid radicals (LOO/LO) if the oxidized fatty acid chain swings out to the membrane surface, due to its increased polarity, as suggested previously 42

Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet beta-cells