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The impaired wound healing response observed in smokers can also hinder hepatic regeneration, thereby exacerbating fibrosis and increasing the likelihood of replication errors and de novo mutations, potentially linking to carcinogenesis [47, 48]

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A deviation in the diameter can cause problems such as poor appearance, uneven burning, tar and nicotine variation, problems in the packaging process and potential customer complaints

These studies also estimate that 324,000 to 654,000 smoking attributable deaths overall (92,000 to 238,000 among African Americans) would be avoided over the course of 40 years

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doi:10.1016/j.jinf.2013.05.004