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Given the lack of understanding regarding pathophysiological causal factors in IC/BPS and the consequence that treatment goals are to control symptoms to optimize QoL, the Panel judged that the most appropriate course was to preserve treatments as clinical choices as long as some efficacy for some patients was demonstrated and the risk of serious harms was low

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Arron HE, Marsh BD, Kell DB, Khan MA, Jaeger BR, Pretorius E

An early administration of high ASA doses showed a neuroprotective effect in MPTP mice, while other COX-2 inhibitors including ibuprofen did not (226)

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