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10.1038/s41588-024-01662-5 21 HuangC.WangG.YuanY.ZouY.TangX.GuoH.et al (2025)

This would be consistent with findings that many proteins impacted by APOE genotype in the brain are upregulated in young APOE4 carriers yet downregulated in older individuals with AD (Roberts et al., 2021)