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However, astrocytes and microglia are profoundly altered structurally and functionally in the aged brain, and these changes extend to the cells and structures they support (Figure 2A)

Despite promising evidence, important gaps remain

These cells secrete various mediators that are directly responsible for the progression of allergy and bronchial obturation in asthma ( de novo synthesized prostaglandin D2 (PGD2), leukotriene C4 (LTC4), adenosine, and ROS are released from mast cell granules ( Figure 1 )

10.1523/JNEUROSCI.3968-04.2004 150 YangC.WangC.WangM.QinX.HaoG.KangM.et al (2021)

3 Once activated by infection, neutrophils are rapidly recruited to sites of inflammation in the lungs, where they produce and secrete cytokines, enzymes, including elastase (NE), reactive oxygen species (ROS) by oxidative burst, and finally release DNA to form neutrophil extracellular traps (NETs)

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