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2009;296(3):F496504

However, its important to note that B12 shots are most beneficial for those who are truly deficient

, 194 , 965-971, Tengg, M., Stecher, H., Offner, L., Plasch, K., Anderl, F., Weber, H., Schwab, H., and Gruber-Khadjawi, M

Those non-covalent compounds are highly specific and since they bind reversibly, they may exhibit a better safety profile ( in vivo activity (Zhuang et al., 2017), potentially because they are highly polar and hardly able to penetrate the BBB