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Several studies (Table 3) have shown that LA significantly reduces body fat mass, hepatic clearance of TG-rich lipoproteins, and lipid droplets through upregulating the expression levels of hepatic lipolytic enzymes (ATGL, acyl-CoA thioesterase [Acot1], Acot2, Acsf2, and Crat) and downregulating the expression levels of liver lipogenic enzymes (patatin-like phospholipase domain protein [Pnpla3], Pnpla5, Elovl6, Acly, sn-glycerol-3-phosphate acyltransferase 1 [Gpat], Aacs, FASN, ACC, and SCD-1)

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Jackson and Theiss, 2020

Synthesized DNA with predefined DNA methylation patterns would be one option, but this is currently feasible only for fully methylated DNA spiked into fully unmethylated DNA, thus ignoring the challenges posed by heterogeneous DNA methylation patterns 64

Hence, the findings discussed here provides valuable insights into the mechanisms behind this resistance and offers potential pathways for future cancer treatments, particularly those involving the targeting of both c-myc and glutamine metabolism