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Journal of Alternative and Complementary Medicine, 17 (9), 827-833

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This fatal neurodegenerative disease has a worldwide prevalence of 4-6 cases in 100,000 and typically has a late-onset with symptoms arising between 55 and 65 years of age, on average [3]

Recently, exhaustion of GSH in cisplatin-resistant cells has been extensively utilized to strengthen the cytotoxicity of cisplatin and sensitize chemotherapy ( Platinum precursors such as Pt () are applied to produce Pt () as a GSH-scavenging agent

these may cross the blood-brain barrier to promote neurodegenerative processes

Even exosomes derived from camel milk can reduce oxidative stress and restore intestinal barrier integrity through the FXR/NF-B pathway [480], suggesting that exosomes derived from plants, animals, and humans can serve as portable activators of FXR signaling