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These findings are consistent with previous reports demonstrating the significant decline of CB 1 binding sites in several brain areas, including the mesolimbic system following chronic administration of cannabinoids in animals ( 1 receptors

NNMT predominantly localizes in adipose tissue and liver (Aksoy et al., 1994)

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Nat Rev Mol Cell Biol 11: 834848 [DOI] [PubMed] [Google Scholar] Trusolino L., Comoglio P.M