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The water-soluble nature of B12 means several things for patients : the vitamin requires regular dietary intake to maintain optimal levels, it can be lost during food preparation (particularly with prolonged cooking or boiling), and therapeutic doses are generally considered safe as excess is eliminated through the kidneys, though the body's substantial hepatic storage also plays a role in B12 metabolism

The Kuceki et al

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Preventive steps If you must use acetaminophen or any medication that carries with it the warning that it could cause liver damage, why not offer yourself some protection by taking a regular, daily cocktail of milk thistle, turmeric, green tea and/or artichoke along with a large serving or two of cruciferous vegetables