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The development of targeted resveratrol liposomes modified with DQA-PEG (2000)-DSPE on the liposome surface significantly enhance cellular uptake and selectively accumulate in mitochondria

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Mutations in MMAA , MMAB , and MUT (corresponding to cblA, cblB, and mut complementation groups) are associated with isolated methylmalonic aciduria, while mutations in MTRR and MTR (corresponding to cblE and cblG complementation groups) are associated with isolated homocystinuria

Current evidence indicates that, across multiple models, 4-HNE activates inflammasomes, promotes calcium overload, impairs autophagylysosome flux, and interferes with transcriptional regulation and mRNA stability by modifying nuclear or RNA-binding proteins (Xiao Liang, 2024